Lhasa Limited shared knowledge shared progress

Publications

The following links provide access to relevant publications for the last 2 years. If you would like to view older publications, or to refine your search criteria further please search the library.

TitlePublishedTypeProducts
Improving In Silico Predictions in Developmental and Reproductive ToxicologyApril 2019Derek NexusSarah Nexus
Improving In Silico Predictions in Developmental and Reproductive ToxicologyMarch 2019pdf file
Enhancing the ICH M7 Workflow Through SetariaMarch 2019pdf fileSetaria
A defined approach for predicting skin sensitisation hazard and potency based on the guided integration of in silico, in chemico and in vitro data using exclusion criteriaJanuary 2019Derek NexusVitic Nexus
Important considerations for the validation of QSAR models for in vitro mutagenicityNovember 2018Derek NexusSarah NexusVitic Nexus
Zeneth: an in silico tool to aid identification of degradantsOctober 2018pdf fileZeneth
Webinar - A defined approach for predicting skin sensitisation hazard and potency.October 2018
In Silico Predictions For GenotoxicityOctober 2018pdf fileDerek NexusSarah Nexus
Meeting report, ICH M7 relevant workshop: use of (Q)SAR systems and expert judgmentSeptember 2018pdf fileDerek NexusSarah Nexus
Development Of A Network Of Adverse Outcome Pathways (AOPs) For CarcinogenicitySeptember 2018pdf fileVitic NexusDerek NexusSarah Nexus
A pharma-wide approach to address the genotoxicity prediction of primary aromatic amines.June 2018
Toxicity Studies for Degradation Impurities - An Industry PerspectiveJune 2018pdf fileDerek NexusSarah Nexus
Sarah Nexus Strain InformationMarch 2018pdf fileSarah Nexus
Vitic: Lhasa’s Toxicity Information Management SystemMarch 2018pdf fileVitic Nexus
An Overview of Recent Skin Sensitisation Work at LhasaMarch 2018pdf fileDerek Nexus
Using New Features to Further Interrogate Sarah Nexus PredictionsMarch 2018pdf fileSarah Nexus
Strain profiles: Moving beyond binary Ames classificationMarch 2018pdf fileSarah Nexus
In Silico Prediction of DILI - Extraction of Histopathology Data from Preclinical Toxicity Data Studies of the eTOX Database for new In SIlico Models of HepatotoxicityMarch 2018pdf fileETOX
Derek Nexus BrochureJanuary 2018pdf fileDerek Nexus
Skin Sensitisation BrochureJanuary 2018pdf fileDerek NexusVitic Nexus
Derek Nexus Carcinogenicity QMRF.pdfDecember 2017pdf fileDerek Nexus
Derek Nexus Chromosome Damage QMRF.pdfDecember 2017pdf fileDerek Nexus
Derek Nexus Mutagenicity QMRF.pdfDecember 2017pdf fileDerek Nexus
Derek Nexus Skin Sensitisation QMRF.pdfDecember 2017pdf fileDerek Nexus
Derek Nexus HERG QMRF.pdfDecember 2017pdf fileDerek Nexus
Derek Nexus Teratogenicity QMRF.pdfDecember 2017pdf fileDerek Nexus
Drug Master File (DMF) Holders Preferred PGI Control Strategy Under ICH M7 in Support of Abbreviated New Drug Applications (ANDAs)November 2017pdf file
Profilling potential drug-induced hepatotoxicity thorugh modelling molecular initiating events (MIEs)November 2017pdf file
Understanding Negative Predictions in Derek Nexus - A Detailed WorkflowNovember 2017pdf fileDerek Nexus
Understanding Negative Predictions in Derek NexusNovember 2017pdf fileDerek Nexus
An Overview of Lhasa Limited Collaborative Data Sharing InitiativesOctober 2017pdf fileDerek NexusETOXExcipientsIntermediatesVitic Nexus
Carbamates and ICH M7 classification: Making use of expert knowledgeApril 2017Derek NexusSarah Nexus
A quantitative in silico model for predicting skin sensitization using a nearest neighbours approach within expert-derived structure–activity alert spacesMarch 2017Derek Nexus
Developmental and Reproductive Toxicity Predictions in Derek NexusMarch 2017pdf fileDerek Nexus
Computational Systems Pharmacology and Toxicology - Tools for Green Molecular Design to Reduce Toxicological RiskMarch 2017Derek NexusSarah Nexus
Redox cycling versus general liver toxicity: Read-across case study with phenolsFebruary 2017pdf file
Prediction of microvesicular liver steatosis: Read-across case study with VPA analoguesFebruary 2017pdf file
(Q)SAR tools for priority setting: A case study with printed paper and board food contact material substancesFebruary 2017Derek NexusSarah Nexus
Setaria 1.0 Installation GuideDecember 2016pdf fileSetaria
Setaria 1.0 Release NotesDecember 2016pdf fileSetaria
SEND to Vitic 1.0 ReleaseNotes.pdfNovember 2016pdf fileETOXVitic Nexus
Prediction of the effect of formulation on the toxicity of chemicalsOctober 2016
FutureTox III: Bridges for TranslationOctober 2016
Local electrophilicity as a descriptor for toxicity-relevant reactivity: A fragment-based approachSeptember 2016pdf file
Modelling the toxicity of drug-vehicle relationships: a QSAR and knowledge-base approach.July 2016pdf file
Sarah Nexus Mutagenicity QMRF.pdfMay 2016pdf fileSarah Nexus
Mechanistic Expert Call Datasets Support in silico Prediction of Teratogenicity for a Wider Chemical SpaceApril 2016Derek Nexus
Quantitative prediction of skin sensitisation potency based on structural alert spacesApril 2016Derek Nexus
Lhasa Data Sharing Experience at Bristol-Myers SquibbApril 2016pdf fileDerek Nexus
Summation of Toxicity Data in ViticMarch 2016Vitic Nexus
A tool for predicting the purging of (potentially) mutagenic impurities during synthesisMarch 2016pdf fileMirabilis
Mechanistic Expert Call Datasets Provide In Silico Prediction of Teratogenicity for a Wider Chemical SpaceMarch 2016pdf fileDerek Nexus
Quantitative prediction of skin sensitisation potency based on structural alert spacesMarch 2016pdf fileDerek Nexus
Translating from Preclinical In-Life Observations to Human Side Effects (eTOX III)March 2016pdf fileETOX
Integrating Animal Data From The Past With Future CDISC-SEND Compliant Data (eTOX Part VI)March 2016pdf fileETOX
Interpretation and mining of statistical machine learning (Q)SAR models for toxicity predictionFebruary 2016pdf file
Mutagenicity assessment strategy for pharmaceutical intermediates to aid limit setting for occupational exposureJanuary 2016Sarah NexusDerek Nexus
It’s difficult, but important, to make negative predictionsJanuary 2016Derek Nexus
Investigation of an in vitro hepatotoxicity dataset to search for co-occurrence of signals amongst assays.December 2015pdf file
Evaluation Of A Statistics-based Ames Mutagenicity QSAR Model And Interpretation Of The Results ObtainedDecember 2015Sarah Nexus
Development of the EC3 prediction engine in DerekNovember 2015Derek Nexus
CIGAA - Consortium for the Investigation of Genotoxicity of Aromatic Amines.pdfNovember 2015pdf fileZeneth
Capturing and curating in vitro data from diverse sources to support MIE investigation for hepatotoxicityNovember 2015pdf file
Using random forest and decision tree models for a new vehicle prediction approach in computational toxicologyNovember 2015
42nd ICGM Product Update.pdfNovember 2015pdf fileDerek NexusMeteor NexusSarah NexusVitic NexusZeneth
Arylboronic acid genotoxicity - summary of data and knowledge.pdfNovember 2015pdf fileDerek Nexus
Mirabilis: a tool for predicting the purging of mutagenic impurities during synthesisNovember 2015pdf fileMirabilis
ICH M7 Workflow.pdfNovember 2015pdf fileDerek NexusSarah NexusVitic Nexus
The implementation of potency predictions for skin sensitisation in Derek Nexus.pdfNovember 2015pdf fileDerek Nexus
Lhasa's scientific approach to potency prediction for skin sensitisation.pdfNovember 2015pdf fileDerek Nexus
Why data sharing is important - a case study using proprietary mutagenicity and skin sensitisation data.pdfNovember 2015pdf fileDerek Nexus
Using In Vitro Structural Alerts For Chromosome Damage to Predict In Vivo Activity and Direct Future TestingSeptember 2015Derek Nexus
Structure-Activity Relationships for Respiratory Sensitisation and Occupational Asthma Caused by Low Molecular Weight ChemicalsSeptember 2015pdf fileDerek Nexus
Using in vitro structural alerts for chromosome damage to predict in vivo activity and direct future testingJuly 2015Derek Nexus
Examples of expert systems for toxicity and metabolism predictionJune 2015pdf fileDerek NexusMeteor Nexus
Derek Web ServicesMay 2015pdf file
A practical application of two in silico systems for identification of potentially mutagenic impuritiesMay 2015Derek NexusSarah Nexus
Establishing Good Practice in the Use of Computer PredictionApril 2015
Analysis of human and in vivo data for hepatotoxicity modellingApril 2015Derek Nexus
Examining the role of in silico assessment in skin sensitisation integrated testing strategiesApril 2015Derek Nexus
Building models of bacterial mutagenicity from biased training data.pdfMarch 2015pdf fileSarah Nexus
Examining the role of in silico assessment in skin sensitisation integrated testing strategies.pdfMarch 2015pdf fileDerek Nexus
Analysis of human and in vivo data for hepatotoxicity modelling.pdfMarch 2015pdf fileDerek Nexus
(Q)SAR assessments of potentially mutagenic impurities: A regulatory perspective on the utility of expert knowledge and data submissionMarch 2015
Adding In Vivo Mammalian Cytogenetics Data to SEND and ToxML.pdfMarch 2015pdf file
Prediction of genotoxic potential of cosmetic ingredients by an in silico battery system consisting of a combination of an expert rule-based system and a statistics-based systemJanuary 2015Derek Nexus
Introduction to in silico toxicologyOctober 2014Derek NexusSarah Nexus
The eTOX Data-Sharing Project to Advance in silico Drug-Induced Toxicity PredictionOctober 2014ETOXVitic Nexus
Building Models within Sarah Nexus.pdfSeptember 2014pdf fileSarah Nexus
Derek Nexus predicts human skin sensitisation accurately. What is the rationale behind its predictive performance?.pdfSeptember 2014pdf fileDerek Nexus
Utilising Knowledge Relating To 5a-Reductase Inhibition In The Prediction Of Teratogenicity.pdfSeptember 2014pdf fileDerek Nexus
Derek Nexus predicts human skin sensitisation. What is the rationale behind its predictivity?September 2014Derek Nexus
Utilising Knowledge Relating to 5α-Reductase Inhibition In The Prediction of TeratogenicitySeptember 2014Derek Nexus
38th ICGM Product Update.pdfSeptember 2014pdf fileDerek NexusMeteor NexusSarah NexusVitic NexusZeneth
Potentially Mutagenic Impurities (PMIs): Optimizing Toxicological and Analytical AssessmentsJuly 2014
A Collaborative Approach towards Risk Assessment for Mutagenic Impurities.pdfJuly 2014pdf fileMirabilis
Emerging Pattern Mining to Aid Toxicological Knowledge DiscoveryMay 2014
Benchmarking Assessment of Salmonella Mutagenicity QSAR Models for Potential Use Under ICH M7.pdfMarch 2014pdf fileSarah Nexus
Can public data improve mutagenicity predictions for proprietary compounds.pdfMarch 2014pdf fileDerek Nexus
New transparent statistical approaches to toxicity prediction.pdfMarch 2014pdf fileSarah Nexus
Addressing toxicity risk when designing and selecting compounds in early drug discoveryJanuary 2014Derek Nexus
Application and Development of Negative Predictions in Derek.pdfNovember 2013pdf fileDerek Nexus
Comparative Evaluation of in Silico Systems for Ames Test Mutagenicity Predict.pdfSeptember 2013pdf fileDerek NexusSarah Nexus
Sharing Preclinical Data and Building Ontologies to Enable Better Prediction of Toxicity.pdfSeptember 2013pdf fileETOXVitic Nexus
Collaborative Solutions to ICH M7.pdfJune 2013pdf fileDerek NexusSarah NexusVitic NexusZeneth
Assessing Confidence in Predictions.wmvMay 2013Derek Nexus
The Sarah Engine Prototype.pdfApril 2013pdf fileSarah Nexus
In Silico Systems For The Prediction Of ToxicityJanuary 2013pdf fileDerek Nexus
Food for thought - A toxicology ontology roadmapDecember 2012Derek Nexus
2012 virtual ICGM 8 Mercury.pdfNovember 2012pdf file
2012 virtual ICGM 8 Sarah.pdfNovember 2012pdf fileSarah Nexus
Assessing confidence in predictions made by knowledge-based systemsSeptember 2012Derek Nexus
A Tool to Assist Toxicological Knowledge Development by Mining Emerging Patterns from Toxic.pdfSeptember 2012pdf fileDerek Nexus
2012 vICGM 3 Collaborative Data Sharing.pdfMay 2012pdf fileETOXMIP DILIVitic Nexus
Vitic Nexus - Interrogation of existing data for toxicity assessment .pdfMarch 2012pdf fileVitic Nexus
Expert Systems - The Use of Expert Systems in Drug Design-Toxicity and MetabolismJanuary 2012Derek NexusMeteor Nexus
The use of in silico tools to reduce toxicity testing.pdfOctober 2011pdf fileDerek NexusIntermediatesVitic Nexus
Combined Use of a Database and an Expert System as an In Silico Tool for Predicting Toxicity.pdfSeptember 2011pdf fileDerek NexusVitic Nexus
The Role of Partnerships in Advancing the 3Rs - Together it is Possible.pdfSeptember 2011pdf fileExcipientsIntermediatesVitic Nexus
Defining Applicability Domains for Structural Alerts for Mutagenicity.pdfNovember 2010pdf fileDerek Nexus
In silico systems conforming to the OECD Principles for (Q)SAR Validation.pdfNovember 2010pdf fileDerek Nexus
A Data Sharing Initiative on the Toxicity of Excipients.pdfNovember 2010pdf fileVitic Nexus
The use of a published data set for the development of new structure-activity relationship (SAR) alerts for skin sensitisationSeptember 2010pdf fileDerek Nexus
Developing Structure-Activity Relationships for the Prediction of HepatotoxicityJune 2010Derek NexusMIP DILI
Derek for Windows - an example of a Knowledge-Based Prediction System.pdfJune 2010pdf fileDerek Nexus
A knowledge-based approach to the in silico assessment of toxicity .pdfMay 2010pdf fileDerek NexusMeteor Nexus
Development of Structure-Activity Relationships for Hepatotoxicity Using Proprietary Data.pdfApril 2010pdf fileDerek Nexus
Towards Establishing Good Practice in the Use of Computer Prediction.pdfApril 2010pdf file
Using In Silico Tools in a Weight of Evidence Approach to Aid Toxicological AssessmentJanuary 2010Derek Nexus

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