Derek NexusDerek Nexus is the expert, knowledge-based software that gives you accurate toxicity predictions quickly. Early, accurate in silico toxicity tests using Derek Nexus is the quick, inexpensive way to identify potentially toxic chemicals, aiding your experts in rejecting unsuitable drug candidates.MirabilisMirabilis is an industry-standardised approach providing an expert and scientifically robust software for the calculation of purge factors of potentially mutagenic impurities in a synthetic route.Sarah NexusSarah Nexus is a statistical software tool that gives you accurate mutagenicity predictions quickly.ViticVitic is the next generation chemical database and information management system, offering researchers and scientists rapid access to searchable toxicological information. Early review of Vitic is the quick, inexpensive way to identify potentially toxic chemicals, and therefore reject unsuitable drug candidates.
Vitic Nexus is your trusted toxicity expert and management system; containing data implemented by scientists at Lhasa Limited, who continually work on the toxicity database with current toxicological knowledge.ZenethZeneth is an expert, knowledge-based software that gives you accurate forced degradation predictions quickly. Zeneth is the perfect cost-effective solution for scientists who need to understand the forced degradation pathways of organic compounds.
Zeneth is your trusted degradation expert system. It is based on data implemented by scientists at Lhasa Limited, who continually work on the transformation knowledge base with current transformation knowledge.
This FAQs section details frequently asked questions about the ICH M7 guidelines. For FAQs on Lhasa products, please refer to the relevant product area.
The guidelines state that "Two (Q)SAR prediction methodologies that complement each other should be applied. One methodology should be expert rule-based and the second methodology should be statistical based." What methodologies do Lhasa Limited provide?
Lhasa Limited is able to offer you an integrated solution that provides you with predictions for both methodologies.
- Derek Nexus - an expert rule-based system for the prediction of toxicity.
- Sarah Nexus - a statistical system for the prediction of mutagenicity.
Derek Nexus and Sarah Nexus can be run from within the same Nexus interface to simplify your workflow, however it is important to remember that they are completely separate systems, providing completely independent predictions and reports.
Lhasa Limited also provides:
- Zeneth - to assist in the identification of degradants
- Vitic - to assist in the data review
For a suggested workflow, please refer to Figure 1
in our ICH M7